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Multiple attention region gene co-term network research in the people shows distinctive line of gender-certain transcriptional signatures inside males and females which have MDD
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Modules in males and females with MDD are enriched for cell-type specific genes. Stacked bar graphs showing modules enriched for genes expressed in particular cell types in a, male MDD and b, female MDD. The y axis represents module size defined by number of genes within each module. Modules are defined by an arbitrary color name and are clustered by module differential connectivity (MDC) as gain of connectivity (GOC), loss of connectivity (LOC) and conserved. There is no module associated with a LOC in females with MDD. Enrichment is determined by corrected Fisher’s Exact Test p-value and is listed only for modules that reached significance (FDR p<0.05).
Expanded Shape 7
Gene co-expression modules in males with MDD are enriched for DEGs across brain regions. a, Topological overlap matrix (TOM) plots for control and b, MDD modules in males. Light color represents low topological overlap and progressively darker red color represents higher overlap. Each module is assigned by a unique color. c, Circos plots displaying the degree of enrichment for DEGs (p<0.05)>Extended Figure 8
a good, Schematic representation of your behavioural paradigm regularly gauge the effect off DUSP6 downregulation from the vmPFC of women. Behavioural outcomes from DUSP6 downregulation in the women vmPFC in the b, pushed swim try (FST), c, open field take to (OFT), and you may d, raised and additionally network (EPM). e, Schematic sign of your own behavioral paradigm familiar with assess the feeling from DUSP6 overexpression in females after the sub-persistent variable worry. Bottom chart shows the newest HSV-mediated overexpression off DUSP6 within the infra- and you will prelimbic side of the vmPFC for the mice. Behavioural consequences out of DUSP6 viral overexpression about f, novelty-supressed giving test (NSF) and you will g, sucrose liking shot. (more…)